Neural inflammation and the microglial response in diabetic retinopathy
نویسندگان
چکیده
منابع مشابه
Microglial changes occur without neural cell death in diabetic retinopathy
Very early neuroglial changes have been observed to precede major vascular changes in the retina of diabetic patients and animal models. We investigated the sequence of these neuroglial changes further, in mice with alloxan-induced diabetes. Diabetes was induced by a single injection of Alloxan into C57/Bl6 mice, which subsequently received daily insulin injections. Diabetic and control animals...
متن کاملInflammation and Diabetic Retinopathy
Diabetic retinopathy (DR) is the leading cause of blindness in working-age individuals. There is increasing evidence that established risk factors for DR, including duration of diabetes, hyperglycemia, and hypertension, only explain a limited amount of the variance in the risk of DR. Furthermore, the underlying pathogenesis of DR remains inadequately understood. Diabetes causes metabolic and ph...
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OBJECTIVE To investigate microglial activation in human diabetic retinopathy. METHODS Paraffin sections from 21 eyes of 13 patients with diabetic background, preproliferative, or proliferative retinopathies and 10 normal eyes of 9 individuals were studied with immunolabeling of microglia with antibodies against HLA-DR antigen, CD45, or CD68. RESULTS In the healthy human eyes, ramified micro...
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Diabetic retinopathy (DR) is a significant cause of global blindness; a major cause of blindness in the world.There is emerging evidence that retinopathy is initiated and propagated by inflammation and angiogenesis. Increased cytokines and growth factors, in conjunction with redox stress, contribute to the development and progression of DR of abnormalities of endothelial cells and pericytes in DR.
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Diabetic retinopathy (DR), the most common microvascular complication of diabetes mellitus, is estimated to be the leading cause of new blindness in the working population of developed countries. Primary interventions such as intensive glycemic control, strict blood pressure regulation, and lipid-modifying therapy as well as local ocular treatment (laser photocoagulation and pars plana vitrecto...
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ژورنال
عنوان ژورنال: Journal of Ocular Biology, Diseases, and Informatics
سال: 2011
ISSN: 1936-8445
DOI: 10.1007/s12177-012-9086-x